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2008 | 2007 | 2006 | 2001 | 2000 | 1994 or older
2009
- November: Trained on "Tapping Social Media for Market Analysis" at joint American Marketing Association & SCIP seminar
- Summer/Fall 2009 BioPharma Pulse is here. Subscribe now for your copy! (free for qualified subscribers)
- October: Trained on "Quality and Compliance in Medical Communications", Drug Information Association webinar
- June: Learn from Dr Hughes' article on regulatory changes for 2009 in the AMWA Journal ; Winter/Spring 2009 BioPharma Pulse now available
- May: Panelist speaking on "Secrets of a Medical Education Writer and More" at AMWA New England Chapter meeting
- March: Trained on "Using Active Pharmaceutical Ingredient Intelligence to Forecast Generic Competition" SCIP webinar and "Increasing Your Intelligence ROI" SCIP seminar
- February: Trained on current regulatory environment at "DIA Marketing Pharmaceuticals in a Time of Change" conference
- January: Trained at "Searching Through CI Eyes" and "How to Navigate Turbulent Markets" SCIP webinar and seminar
2008
- November: Trained on "Benchmarking for Insight on R & D Productivity" and "When War Games Don't Work and How to Fix Them" SCIP webinars
- October: All new Hughes BioPharma Web Site launched! Try out interactive features by visiting our blog or tell us your opinion by taking our poll (home page).
- July: Dr Hughes launches new venture authoring medical thrillers. Visit blog at www.candicehughes.com.
- January: New audio training CD available for sale: Gaining Clients Through Marketing Savvy
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2007
- AMWA National Conference (Atlanta, Georgia): Dr Hughes presents Gaining Clients Through Marketing Savvy
- Dr Hughes selected for AMWA Web and Technology Committee (2007-2008)
- Project management strategies for medical writers and editors click to View project management article
- Pharmaceutical and biotech technology assessment on a slim budget: Secondary sources click to view PDF document
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2006
June 19, 2006- In Business Week, Dr Hughes Comments on Pharma Industry
"Reevaluation of gold-standard treatments is a good start on the path to more effective and efficient health care.
However, your Cover Story overlooked the key reason why we have costly, inefficient health care today: The system
is designed for crisis management rather than for fostering optimal health. A top-to-bottom restructuring with changes
in incentives is needed for every party, including insurers, health-care providers, employers, and patients. All other
changes are like putting duct tape on a leaking pipe."
- Candice M. Hughes, PhD, Hughes BioPharma Advisers LLC. Feedback,
Medical Guesswork. Business Week, June 19, 2006, page 56.
- AMWA, New England Chapter (New Haven, Connecticut): Dr Hughes presents CME Evolution: Surviving and Thriving in a New World
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2001
- AMWA National Conference (Norfolk, Virginia): Dr Hughes discusses interdepartmental teamwork: marketing, sales and editorial
- Marketing, sales, and editorial: Making peace click to View PDF of article
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2000
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1994 or older
- J Neurosci. 1994 Apr;14(4):2225-35.
Increased levels of hemoglobin-derived and other peptides in Alzheimer's disease cerebellum.
Slemmon JR,
Hughes CM,
Campbell GA,
Flood DG.
Department of Biochemistry, University of Rochester Medical Center, New York 14642.
Several studies point to the importance of peptides and proteolysis in Alzheimer's disease (AD). Because of its ability to study small proteins and peptides, reverse-phase HPLC was employed to study these species in AD. Cerebellum was chosen for these initial studies because it does not show significant neuronal loss but does show some pathology in AD. Examination of over 600 peptide peaks per case revealed 15 that were elevated in AD. Nine were fragments of hemoglobin, and the remainder included two species of calmodulin, two of myelin basic protein, and one each of 67 kDa neurofilament protein and PEP-19. The cleavage sites on hemoglobin were after hydrophobic residues and immunolocalization was seen preferentially around blood vessel walls and granule cells. The elevation of the non-serum-derived peptides was characteristic of general metabolic changes that occurred in AD cerebellum, and the presence of elevated hemoglobin polypeptides indicated either possible disruption of the blood-brain barrier or selective evasion of it by peptidaceous products. Further studies are required to establish whether hemoglobin fragments have a role in neurodegenerative processes such as AD.
PMID: 7512635 [PubMed - indexed for MEDLINE]
For more information, click on this link to PubMed.
- Anat Embryol (Berl). 1992 Jul;186(2):183-93.
Types of callosally projecting nonpyramidal neurons in rat visual cortex identified by lysosomal HRP retrograde labeling.
Hughes CM,
Peters A.
Department of Anatomy and Neurobiology, Boston University School of Medicine, MA 02118.
Callosally projecting neurons, labeled following injection of horseradish peroxidase (HRP) into the 17/18a border of the contralateral hemisphere, have been examined by light and electron microscopy. These neurons exhibit two types of horseradish peroxidase labeling: either a diffuse, Golgi-like labeling, or a granular, punctate labeling. The punctate type of HRP-labeling is the predominant form in nonpyramidal neurons, while pyramidal neurons frequently display either diffuse or punctate labeling. Only punctately labeled neurons have been examined in this study. Light microscopic analyses of 1-microns sections show that in the heavily labeled zone at the area 17/18a border approximately 9% of all of the cells in layer II/III are callosally projecting nonpyramidal cells, and 70% of them are callosally projecting pyramidal cells. Light and electron microscopic examinations indicate that the nonpyramidal neurons are a heterogeneous group which consists of small multipolar neurons, large multipolar neurons, small bipolar neurons, and large bipolar neurons. To investigate the ultrastructural appearance of the punctate HRP labeling, selected neurons have been examined in thin sections. In the electron microscope, the tetramethylbenzidine (TMB) reaction product appears as electron-dense crystals, while the diaminobenzidine (DAB) reaction product appears as dark, electron-dense material which fills the lysosomes. These lysosomes occasionally have a halo of reaction product, but often they are not morphologically distinguishable from dark lysosomes present within neurons from control animals in which the darkening results from staining the thin sections with lead citrate and uranyl acetate. However, labeled neurons possess more dark lysosomes than neurons from control animals. These additional dark lysosomes presumably contain the HRP reaction product visible by light microscopy.
PMID: 1510248 [PubMed - indexed for MEDLINE]
For more information, click on this link to PubMed.
- Brain Res. 1992 Jun 26;583(1-2):271-8.
Symmetric synapses formed by callosal afferents in rat visual cortex.
Hughes CM,
Peters A.
Department of Anatomy and Neurobiology, Boston University School of Medicine, MA.
Following an electron microscopic examination of 437 degenerating terminals of callosally projecting axons in layer II/III at the 17/18a border, it has been found that some of these terminals form symmetric synapses with dendritic shafts (1.83%), pyramidal cell bodies (1.37%) and dendritic spines (0.46%). The remainder of the axon terminals (96.33%) form asymmetric synapses, mainly with dendritic spines although a few form synapses with dendrites. These results suggest that in the rat visual cortex the corpus callosum is a source of both inhibitory and excitatory input to the contralateral hemisphere.
PMID: 1504833 [PubMed - indexed for MEDLINE]
For more information, click on this link to PubMed.
- Anat Embryol (Berl). 1990;182(6):591-603.
Morphological evidence for callosally projecting nonpyramidal neurons in rat visual cortex.
Hughes CM,
Peters A.
Department of Anatomy and Neurobiology, Boston University School of Medicine, MA 02118.
This investigation shows that some of the callosally projecting neurons in rat visual cortex are nonpyramidal cells. Callosally projecting neurons were labeled by injections of horseradish peroxidase (HRP) into the area 17/18a border zone of the contralateral hemisphere. The retrogradely transported HRP was visualized with diaminobenzidine or with tetramethylbenzidine. In some of the labeled neurons the reaction product was diffuse, so that the neurons had a Golgi-like appearance, but in others the reaction product was granular, or punctate. The majority of neurons with a Golgi-like appearance were pyramidal cells, but one callosally projecting neuron from layer V area 18a was confirmed by electron microscopy to be a nonpyramidal neuron. This dearth of well-filled nonpyramidal cells suggested that callosally projecting nonpyramidal neurons may not transport sufficient HRP to show Golgi-like filling, and so punctately labeled neurons from areas 17, 18a and 18b were examined. Reacted sections from areas 17, 18a and 18b of control animals, into which no tracer had been injected, were also examined, but in these control preparations no granules similar to the HRP granules within the neuronal profiles of the experimental animals were encountered. In methylene blue-stained 1-microns sections, neuronal profiles from the control animals possessed only blue staining lysosomes, while neuronal profiles from the experimental animals exhibited both lysosomes and HRP granules. It was determined, from the counts of HRP granules in neurons from the experimental animals, that in selected regions of areas 17, 18a, and 18b similar percentages of the pyramidal and nonpyramidal neuronal populations (ranging from 100% to 34%) contained HRP granules, and so had callosally projecting axons. However, most callosally projecting nonpyramidal neurons had far fewer HRP granules than the pyramidal neurons, again indicating that they transport less HRP. This could account for the fact that callosally projecting nonpyramidal neurons only rarely show a Golgi-like filling, and this could be one reason why such cells have been overlooked in most previous studies.
PMID: 2075917 [PubMed - indexed for MEDLINE]
For more information, click on this link to PubMed.
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